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KMID : 0359320220620040003
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Korean Journal of Veterinary Research
2022 Volume.62 No. 4 p.3 ~ p.3
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Neuronal ceroid lipofuscinosis in a Border Collie: a case report
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Seo Min-Su
Koo Yoon-Hoi
Choi Dong-Joon
Kim Sang-Gu
Yun Tae-Sik
Chae Yeon
Lee Do-Hee
Kim Hak-Hyun
Yang Mhan-Pyo
Kim Soo-Chong
Kang Byeong-Teck
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Abstract
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A 2-year-old spayed female Border Collie presented with visual deficits and behavioral changes. Neurological examination revealed bilateral menace response deficit with a normal pupil light reflex. Cerebral cortical thinning, cerebral sulci and cerebellar fissure widening, ventriculomegaly, and cerebral atrophy were observed on magnetic resonance imaging (MRI). Histopathology revealed fluorescent lipopigment accumulation in the cerebrum, and the dog was diagnosed with neuronal ceroid lipofuscinosis. This is the first case report describing the changes in clinical signs, MRI findings, and histopathologic changes in neuronal ceroid lipofuscinosis in Korea.
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KEYWORD
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dogs, lysosomal storage diseases, neuronal ceroid-lipofucinoses, congenital abnormalities, aggression
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